The cells that are repeatedly exposed to inflammatory mediators will have the genes that code for inflammatory response proteins switched on, and thus be in a constant state of inflammation. This leads to diseases and health conditions that are strongly linked to inflammation, including asthma and cardiovascular diseases. Some of the molecules in the body that can instigate a change in gene expression are: Nf-kB, TNFa, and reactive nitrogen species such as nitric oxide and peroxynitrite.